| Primary Identifier | MGI:3800816 | Allele Type | Transgenic |
| Attribute String | Recombinase | Gene | Tg(HBB-cre)12Kpe |
| Strain of Origin | C57BL/6 | Is Recombinase | true |
| Is Wild Type | false |
| molecularNote | A transgenic construct containing the sequence encoding Cre recombinase under the control of the human beta hemoglobin (HBB) promoter, intron 2-enhancer fragment, and the human beta hemoglobin locus control region (LCR) was introduced into C57BL/6 donor eggs. Founder line 12 was established. Cre recombinase expression is detected in blood, brain, gonads, spleen and liver by RT-PCR analysis and in blood by RNAse protection assay. Recombination occurs at 50-100% efficiency in erythroid/megakarycytic cell lineages beginning at onset of hematopoiesis at approximately embryonic day 7.5. |
