| Primary Identifier | MGI:3808000 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Tnfrsf1a |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A targeting vector was prepared containing nucleotide mutations to produce a T50M mutation in the pre-ligand assembly domain of the gene. Mice were crossed with a Cre recombinase transgenic strain to remove a floxed neomycin selection cassette. Peripheral blood neutrophils from homozygotes have intracellular expression of the mutant protein but fail to express the protein on the cell surface. |
