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Allele : Rhoh<tm1Brak> ras homolog family member H; targeted mutation 1, Cord Brakebusch

Primary Identifier	MGI:3826431	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Rhoh
Transmission	Germline	Strain of Origin	Not Specified
Is Recombinase	false	Is Wild Type	false

molecularNote

A 0.9 kb fragment encoding the first 42 amino acids was replaced with a neomycin resistance cassette. This removes the translation start site and the switch 1 region. Northern blot analysis indicated that no normal protein was expressed.

mutations:
Insertion,
Intragenic deletion

cellLines:
Not Specified

synonyms:
RhoH<->,
RhoH<->

earliestPublication:
Dorn T, et al. (2007) RhoH is important for positive thymocyte selection and T-cell receptor signaling. Blood 109(6):2346-55

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

8 Publication categories

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