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Allele : Tlr6<m2Btlr> toll-like receptor 6; mutation 2, Bruce Beutler

Primary Identifier  MGI:3831304 Allele Type  Chemically induced (ENU)
Gene  Tlr6 Inheritance Mode  Recessive
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false Project Collection  Beutler Mutagenetix
molecularNote  This mutation was discovered in a TLR Signaling Screen of G3 progeny of an ENU mutagenized male mouse. The mutation comprises an A to T transversion at nucleotide position 1501 of the gene (Genbank: NM_011604) that results in conversion of a triplet encoding arginine at amino acid position 457 to a termination codon (R457Ter), truncating the protein by 349 amino acids at its C terminus.
  • mutations:
  • Single point mutation
  • synonyms:
  • MALP-2 specific defect 1,
  • MALP-2 specific defect 1,
  • msd1,
  • m2sd1,
  • msd1,
  • m2sd1
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

3 Publication categories