Primary Identifier | MGI:3831304 | Allele Type | Chemically induced (ENU) |
Gene | Tlr6 | Inheritance Mode | Recessive |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false | Project Collection | Beutler Mutagenetix |
molecularNote | This mutation was discovered in a TLR Signaling Screen of G3 progeny of an ENU mutagenized male mouse. The mutation comprises an A to T transversion at nucleotide position 1501 of the gene (Genbank: NM_011604) that results in conversion of a triplet encoding arginine at amino acid position 457 to a termination codon (R457Ter), truncating the protein by 349 amino acids at its C terminus. |