Primary Identifier | MGI:3841156 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Fto |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exons 2 and 3 were replaced with a neomycin resistance cassette. Immunohistochemistry failed to detect protein in the brown adipose tissue, pancreas, liver or stomach of homozygote mice. Expression of the nearby Rpgrip1l gene (Ftm) is unaffected as determined by RT-PCR of hypothalamus, liver, and adipose tissue. |