| Primary Identifier | MGI:3842513 | Allele Type | Targeted |
| Attribute String | No functional change | Gene | a |
| Inheritance Mode | Dominant | Transmission | Germline |
| Strain of Origin | C57BL/6N | Is Recombinase | false |
| Is Wild Type | false |
| description | Although spontaneous revertants of non-agouti retain part of the inserted sequence present in the a allele and are white- or light-bellied agouti (Aw-like), the targeting event that produced Atm1Brd removed the entire insertion, resulting in a fully agouti coat like that of mice bearing the A allele. |
| molecularNote | This mutation deletes the 11.8 kb retrotransposon insertion responsible for the nonagouti phenotype of C57BL/6 mice, along with 607 bp of flanking intronic DNA, with retention of a single frt site from an excised frt-flanked selection cassette. It restores expression of the agouti protein in both dorsal and ventral fur. |
