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Allele : Tph2<tm1.1Kpl> tryptophan hydroxylase 2; targeted mutation 1.1, Klaus-Peter Lesch

Primary Identifier	MGI:3851253	Allele Type	Targeted
Attribute String	Conditional ready, No functional change	Gene	Tph2
Transmission	Germline	Strain of Origin	(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase	false	Is Wild Type	false

molecularNote

A loxP site was inserted upstream of exon 5 and a floxed neo cassette was inserted downstream of exon 5. Transient cre expression in ES cells removed the neo cassette leaving exon 5 floxed.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
Tph2<flox>,
Tph2<flox>

earliestPublication:
Gutknecht L, et al. (2008) Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. J Neural Transm 115(8):1127-32

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

11 Publication categories

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