| Primary Identifier | MGI:3870303 | Allele Type | Gene trapped |
| Attribute String | Null/knockout | Gene | Letm1 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| Project Collection | Sanger Inst. Gene Trap Res. |
| molecularNote | The exogenous gene-trap vector sequence, containing an in-frame splice acceptor site followed by coding sequence for a beta-galactosidase/neomycin (beta-Geo) fusion protein, was inserted into the intron following exon 3 (CC0204). The insertion of a trapping vector after exon 3 creates fusion transcripts and premature stop codons, thus preventing the synthesis of full-length mRNA. Full-length mRNA levels are reduced by 50% in heterozygous mutant mice. |
