Primary Identifier | MGI:4353412 | Allele Type | Chemically induced (ENU) |
Gene | Themis | Inheritance Mode | Recessive |
Strain of Origin | C57BL/6 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | A T-to-A transversion generated a stop codon in place of the sequence encoding a tyrosine residue at position 489. Immunoblot analysis on homozygote thymus extracts detected only a very small amount of truncated protein, and mRNA levels in these extracts were one-third of endogenous levels. |