| Primary Identifier | MGI:4398740 | Allele Type | Targeted |
| Gene | Skil | Transmission | Germline |
| Strain of Origin | 129P2/OlaHsd | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Exon 1 was replaced with a modified exon 1 in which the codons corresponding to the residues 85 through 88 (the R-Smad binding site) and 266 through 267 (the Co-Smad binding site) were altered to code for alanines. A floxed neo cassette was inserted downsteam of the modified exon 1 and subsequently removed by germ line, cre mediated recombination. This allele is predicted to produce a protein product incapable of interacting with R-Smads and Smad4. |
