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Allele : Abl1<tm1Goff> c-abl oncogene 1, non-receptor tyrosine kinase; targeted mutation 1, Stephen P Goff

Primary Identifier  MGI:4421531 Allele Type  Targeted
Attribute String  Conditional ready, No functional change Gene  Abl1
Transmission  Germline Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  A mutated NLS1with 5 amino acid substitutions (Lys to Gly) was introduced into exon 11 and a floxed neo cassette was introduced into intron 10 via homologous recombination. Western blot analysis revealed barely detectable levels of the full length mutant protein and low levels of a fragment consisting of the N terminal half.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • Abl1<m3>,
  • Abl1<m3>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

4 Publication categories