Primary Identifier | MGI:4461135 | Allele Type | Targeted |
Attribute String | Humanized sequence | Gene | Tnfrsf1a |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 2 was replaced with a floxed neo cassette and modified exon 2 in which nucleotide substitutions result in the amino acid substitution of tyrosine for cysteine at position 33 (C33Y), mimicking a mutation associated with TNFR-associated periodic syndrome (TRAPS). Cre mediated recombination removes the neo cassette. |