| Primary Identifier | MGI:4822471 | Allele Type | Targeted |
| Gene | S1pr1 | Transmission | Germline |
| Strain of Origin | (129S6/SvEvTac x C57BL/6)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Nucleotide substitutions in exon 2 result in the amino acid substitution of five serines with alanines (p.[Ser351Ala;Ser353Ala;Ser355Ala] and p.(Ser358_Ser359delinsAlaAla)). This prevents phosphorylization of the five residues and the produced protein fails to internalize correctly, but signaling is not disrupted. A loxP site flanked neomycin resistance gene cassette inserted into intron 2 was removed by subsequent cre-mediated recombination. |
