Primary Identifier | MGI:4830590 | Allele Type | Targeted |
Attribute String | Inserted expressed sequence, Null/knockout | Gene | Kras |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A cassette containing Kras cDNA and a neo was fused in-frame with exon 2 such that synthesis of the endogenous Kras product would be abolished. The rearranged locus was designed to express only the main K-Ras 4B isoform and not the K-Ras 4A protein. |