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Allele : Rr27<tm5.1Msb> regulatory region 27; targeted mutation 5.1, Marisa S Bartolomei
Primary Identifier  MGI:5140188 Allele Type  Targeted
Attribute String  Modified regulatory region Gene  Rr27
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  Using site-directed mutagenesis, the 0.9 kb intervening sequence (IVS) between the CTCF sites was deleted. A floxed neomycin resistance gene cassette inserted downstream of the modified sequence was removed by cre-mediated recombination. The size and CpG content of the imprinting control region (ICR) are decreased 50% and 35%, respectively.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • H19<ICRdeltaIVS>,
  • H19<tm8.1Msb>,
  • H19<ICRdeltaIVS>,
  • H19<tm8.1Msb>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

4 Publication categories





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