| Primary Identifier | MGI:5297247 | Allele Type | Targeted |
| Attribute String | Hypomorph, Inserted expressed sequence | Gene | Gab2 |
| Transmission | Germline | Strain of Origin | C57BL/6Jcl x 129T/SvJcl |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A cDNA encoding amino acids 89-665 was inserted into exon 2, in which nucleotide substitutions result in the amino acid substitution of phenylalanine for tyrosine at positions 603 and 632 abolishing the SHP2-binding domain (Y603F and Y632F). A floxed neo cassette inserted downstream of exon 2 was removed by cre-mediated recombination. |
