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Allele : Ccm2l<tm1Mlkn> cerebral cavernous malformation 2-like; targeted mutation 1, Mark L Kahn

Primary Identifier  MGI:5439489 Allele Type  Targeted
Attribute String  Null/knockout, Reporter Gene  Ccm2l
Transmission  Germline Strain of Origin  129
Is Recombinase  false Is Wild Type  false
molecularNote  A construct including GFP with a nuclear localization tag and an FRT flanked neo cassette was inserted in frame with the start methionine replacing a genomic fragment including most of exon 1 and all of intron 1 and exon 2. GFP is detected in the nuclei of PECAM+ endocardial and endothelial cells. Quantitative real time PCR and RT-PCR confirmed the absence of full length mRNA expression in tissues from homozygous mice.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • Ccm2l<GFP>,
  • Ccm2l<GFP>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories