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Allele : Sirt2<tm1Gdon> sirtuin 2; targeted mutation 1, Gizem Donmez

Primary Identifier	MGI:5467245	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Sirt2
Transmission	Germline	Strain of Origin	Not Specified
Is Recombinase	false	Is Wild Type	false

molecularNote

A puro cassette was inserted into exon 11. Western blot analysis confirmed the absence of all three protein isoforms in the brain.

mutations:
Insertion

cellLines:
Not Specified

earliestPublication:
Liu L, et al. (2012) Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein. J Biol Chem 287(39):32307-11

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

8 Publication categories

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