Primary Identifier | MGI:5471797 | Allele Type | Transgenic |
Attribute String | Dominant negative, Inserted expressed sequence | Gene | Tg(Myh6-Gsk3b*)19Jusa |
Strain of Origin | FVB | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The promoter drives cardiac-specific expression of a modified cDNA in which nucleotide susbtitutions result in the amino acid substitution of methionine for lysine at position 85 (K85M) and isoleucine for lysine at position 86 (K86I). These mutations are predicted to produce a dominant negative product. Line 19 was generated. |