Primary Identifier | MGI:5575394 | Allele Type | Chemically induced (ENU) |
Gene | Themis | Inheritance Mode | Recessive |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false | Project Collection | Beutler Mutagenetix |
molecularNote | ENU mutagenesis induced an A to G transition at base pair 28,782,011 (v38) on chromosome 10, or base pair 113,685 in the GenBank genomic region NC_000076. The mutation results in an arginine (R) to glycine (G) substitution at position 345 (R345G) and is strongly predicted by Polyphen-2 to cause loss of function (score = 1.00). |