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Allele : Slc6a3<tm4.1(tTA)Xz> solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 4.1, Xiaoxi Zhuang
Primary Identifier  MGI:5619093 Allele Type  Targeted
Attribute String  Transactivator Gene  Slc6a3
Transmission  Germline Strain of Origin  129S6/SvEvTac
Is Recombinase  false Is Wild Type  false
molecularNote  The following were inserted, in order, between the promoter and coding sequences of the endogenous gene: tTA-pA-STOP-"PF" [TetO-tTA] cassette-pA-loxP-Neo-loxP. The PF (positive feedback) amplification cassette enhances tTA expression following the removal of the STOP. Cre-mediated recombination removed the downstream floxed neo cassette. Transgene expression is eight-fold higher than endogenous alpha-synuclein expression in dopaminergic neurons.
  • mutations:
  • Insertion
  • synonyms:
  • DAT-PF-tTA,
  • DAT-PF-tTA
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

9 Publication categories





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