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Allele : Mapk6<tm2Melo> mitogen-activated protein kinase 6; targeted mutation 2, Sylvain Meloche

Primary Identifier  MGI:5707044 Allele Type  Targeted
Gene  Mapk6 Transmission  Germline
Strain of Origin  (129S6/SvEvTac x C57BL/6NCrl)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  Lysine codons 49 (AAG) and 50 (AAA) in exon 2 were changed to alanine (GCA) (p.49_50delKKinsAA) and a loxP site flanked neomycin resistance gene was inserted into intron 2. The mutations prevent ATP binding to the kinase and renders it kinase-dead.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • Erk3<KA>,
  • Erk3<KA>,
  • Mapk6<KD>,
  • Mapk6<KD>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

5 Publication categories