Primary Identifier | MGI:5751211 | Allele Type | Targeted |
Attribute String | Conditional ready, Constitutively active, Inserted expressed sequence | Gene | Vav2 |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The targeting contruct introduced downstream of exon 1 a floxed STOP and neomycin resistance cassette, three hemagglutinin (HA) tags, a truncated Vav2 cDNA (delta1-184) and a human growth hormone polyadenylation sequence. This truncated version is a phosphorylation-independent and has constitutitive exchange activity due to the removal of the N-terminal inhibitory domains. |