| Primary Identifier | MGI:5775084 | Allele Type | Targeted |
| Attribute String | Not Specified | Gene | Procr |
| Transmission | Germline | Strain of Origin | 129S2/SvPas |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 2 was replaced with a modified exon in which a point mutation results in the amino acid substitution of arginine with alanine at position 103 (p.R103A) (or position 84 in the mature protein). Flp-mediated recombination removed the FRT site flanked neomycin resistance cassette inserted downstream of the modified exon 2. This variant lacks the ability to bind to protein C/activated protein C (PC/APC). Western blot analysis confirmed normal protein expression in heart, kidney, liver, lung, and spleen tissue lysates from homozygous mutant mice. |
