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Allele : Prdx6<tm2.1Abf> peroxiredoxin 6; targeted mutation 2.1, Aron B Fisher

Primary Identifier  MGI:5812685 Allele Type  Targeted
Gene  Prdx6 Transmission  Germline
Strain of Origin  C57BL/6 Is Recombinase  false
Is Wild Type  false
molecularNote  The targeting vector is designed to insert, by site-directed mutagenesis, a T(CG) to A(CG) point mutation followed by a FRT-flanked neomycin cassette 290 bp downstream of exon 1. The mutation results in an alteration of the corresponding amino acid from serine to threonine (S32T) at codon 32. Flp-mediated recombination removed the FRT-flanked neo cassette. The mutation does not affect phospholipase A2 activity, but does result in impaired trafficking of PRDX6 to the into lamellar bodies and lysosomes of the lung epithelium.
  • mutations:
  • Single point mutation
  • synonyms:
  • Prdx6 S32T,
  • Prdx6 S32T
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

0 Driven By

4 Publication categories