Primary Identifier | MGI:5819100 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Marchf8 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A loxP flanked neomycin selection cassette replaced exons 5 and 6, which encode the catalytically active site in the RING variant (RINGv) domain and the TM domain, respectively. Mice carrying tjhe targeted allele were mated to a CAG-Cre deleter mouse line to remove the neomycin cassette in the final allele. |