|  Help  |  About  |  Contact Us

Allele : Esyt2<tm1.3Sud> extended synaptotagmin-like protein 2; targeted mutation 1.3, Thomas C Sudhof
Primary Identifier  MGI:6101172 Allele Type  Targeted
Attribute String  Constitutively active Gene  Esyt2
Transmission  Germline Strain of Origin  C57BL/6NTac
Is Recombinase  false Is Wild Type  false
molecularNote  Flp-mediated excition of F3 sequences in Esyt2 resulted in the removal of the neomycin selection cassette and endogenous exon 10, leaving a mutant form (D4A) of exon 10. This allele expresses a constitutive mutant protein in which the four C2A-domain Ca(2+) binding sites of the C2A-domain are selectively abolished.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • D4A,
  • D4A
Paste the following link
Quick Links:
SummaryGenomePhenotypeOther
 
Quick Links:
SummaryGenomePhenotypeOther
 
Lists
This Allele isn't in any lists. Upload a list.

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories





MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom