| Primary Identifier | MGI:6118042 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence, Null/knockout | Gene | Lacc1 |
| Strain of Origin | C57BL/6NTac | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR guides introduced a TGT to ATC nucleotide substitutions in exon 5 that results in the amino acid substitution of arginine for cysteine at positione 284 (C284R) plus two downstream silence nucleotide substitutions. This allele mimics the human 'risk' variant for juvenile idiopathic arthritis and early-onset Crohn's disease. |
