| Primary Identifier | MGI:6117843 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Lacc1 |
| Strain of Origin | C57BL/6NTac | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR guides introduced a GTG to ATC nucleotide substitutions in exon 5 that results in the amino acid substitution of isoleucine for valine at positione 254 (V254I). This allele mimics the human protective 'non-risk' variant against leprosy (an infection caused by Mycobacterium leprae) and Crohn's disease. |
