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Allele : Mlkl<tm1.1Wsa> mixed lineage kinase domain-like; targeted mutation 1.1, Warren S Alexander

Primary Identifier	MGI:6251546	Allele Type	Targeted
Attribute String	Conditional ready, No functional change	Gene	Mlkl
Transmission	Germline	Strain of Origin	B6.Cg-Thy1<a>
Is Recombinase	false	Is Wild Type	false

molecularNote

A frt-flanked neomycin resistance cassette was inserted in intron 3 along with loxP sites upstream of exon 3 and immediately downstream of the resistance cassette. The neomycin cassette was removed via Flp-mediated recombination and left exon 3 floxed.

mutations:
Insertion

cellLines:
Not Specified

earliestPublication:
Murphy JM, et al. (2013) The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity 39(3):443-53

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

10 Publication categories

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