Primary Identifier | MGI:6285787 | Allele Type | Endonuclease-mediated |
Attribute String | Modified isoform(s) | Gene | Pcdhg |
Inheritance Mode | Not Specified | Strain of Origin | C57BL/6J |
Is Recombinase | false | Is Wild Type | false |
molecularNote | This allele was generated through shotgun CRISPR/Cas9 editing using pooled sgRNAs that targeted each variable exon of the Pcdhg cluster and this allele was found to have a fusion between exons A5 and B8, and additional junctions between A1 and A4, A12 and A9, and B6 and A6 with an insertion of a transposable element and sequence from Anp32a exons 4-7 3-prime of exon A5, which, in sum, left only the variable exons C3, C4, and C5 intact. |