Primary Identifier | MGI:6295424 | Allele Type | Endonuclease-mediated |
Attribute String | Humanized sequence | Gene | Tuba4a |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false |
molecularNote | CRISPR/Cas9 genome editing is used to introduce a R320C point mutation. The human TUBA4A R320C mutation (arg320-to-cys) is associated with amyotrophic lateral sclerosis 22 without frontotemporal dementia. |