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Allele : Tuba4a<em14Lutzy> tubulin, alpha 4A; endonuclease-mediated mutation 4, Cathy Lutz

Primary Identifier  MGI:6295424 Allele Type  Endonuclease-mediated
Attribute String  Humanized sequence Gene  Tuba4a
Strain of Origin  C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/Cas9 genome editing is used to introduce a R320C point mutation. The human TUBA4A R320C mutation (arg320-to-cys) is associated with amyotrophic lateral sclerosis 22 without frontotemporal dementia.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Tuba4<R320C>,
  • Tuba4<R320C>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

2 Publication categories