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Allele : Grin2b<em5Lutzy> glutamate receptor, ionotropic, NMDA2B (epsilon 2); endonuclease-mediated mutation 5, Cathy Lutz

Primary Identifier	MGI:6283621	Allele Type	Endonuclease-mediated
Attribute String	Conditional ready, No functional change	Gene	Grin2b
Strain of Origin	C57BL/6J	Is Recombinase	false
Is Wild Type	false

molecularNote

CRISPR/Cas9 genome editing is used to insert loxP sequences flanking the second coding exon of Grin2b (exon 4 of Ensembl Grin2b transcript 201/ exon 5 of Ensembl transcript 202).

mutations:
Insertion

earliestPublication:
Munz M, et al. (2023) Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex. Cell 186(9):1930-1949.e31

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

3 Publication categories

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