| Primary Identifier | MGI:6283835 | Allele Type | Endonuclease-mediated |
| Gene | Reck | Strain of Origin | (C57BL/6J x SJL/J)F2 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | CRISPR/Cas9 genome editing is used to insert alanine substitution mutations P256A (nucleotide change: CCT to GCA) and W261A (nucleotide change: TGG to GCC). The mutations eliminate Wnt7a signaling by the Reck gene, but do not affect protein folding or trafficking to the plasma membrane. |
