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Allele : Rr157<em2Fee> regulatory region 157; endonuclease-mediated mutation 2, Ann J Feeney

Primary Identifier	MGI:6303853	Allele Type	Endonuclease-mediated
Attribute String	Modified regulatory region	Gene	Rr157
Strain of Origin	Not Specified	Is Recombinase	false
Is Wild Type	false

molecularNote

A 400 bp sequence in Igk variable region enhancer E88 spanning E2A and EBF binding sites, was deleted in mice using CRISPR/Cas9 genome editing.

mutations:
Intragenic deletion

synonyms:
Igk<em2Fee>,
small E88delta,
Igk<em2Fee>,
small E88delta

earliestPublication:
Barajas-Mora EM, et al. (2019) A B-Cell-Specific Enhancer Orchestrates Nuclear Architecture to Generate a Diverse Antigen Receptor Repertoire. Mol Cell 73(1):48-60.e5

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

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