| Primary Identifier | MGI:6323555 | Allele Type | Targeted |
| Attribute String | Conditional ready, Humanized sequence | Gene | Rit1 |
| Transmission | Germline | Strain of Origin | C57BL/6NTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The targeting vector contains an FRT-flanked neo, exons 4 through 6 of the Rit1 gene immediately followed by a STOP cassette, a polyadenylation sequence, a F3-site flanked PURO cassette, sequence for exon 4 and mutant exon 5 (containing the M90I point mutation). Flp-mediated recombination removed the FRT-flanked neo cassette. The M90I mutation is associated with a mutation found in patients with Noonan syndrome. |
