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Allele : Dicer1<em1Glo> dicer 1, ribonuclease type III; endonuclease-mediated mutation 1, Guillermina Lozano

Primary Identifier  MGI:6364599 Allele Type  Endonuclease-mediated
Attribute String  Constitutively active Gene  Dicer1
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  This allele was generated using CRISPR/Cas9 technology with an sgRNA and a template oligonucleotide. Serine codon 1712 (TCT) was replaced with a aspartic acid codon (GAC), which creates a phosphomimetic p.S1712D mutation that leads to a constitutively active enzyme.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Dicer<S1712D>,
  • Dicer<S1712D>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories