| Primary Identifier | MGI:6477947 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Nkx2-3 |
| Transmission | Germline | Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 2 was disrupted by the insertion of a construct containing IRES-NLS-lacZ followed by a floxed hygromycin selection cassette. The deleted region included nucleotides 2561 through 2860 (amino acids 149-251) encoding encoding the homeodomain and a conserved NK2-specific domain. Expression of beta-galactosidase was driven by the endogenous promoter. Cre-mediated recombination removed the selection cassette. |
