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Allele : Ccdc8<tm1.2Yxi> coiled-coil domain containing 8; targeted mutation 1.2, Yue Xiong

Primary Identifier	MGI:6695964	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Ccdc8
Transmission	Germline	Strain of Origin	129P2/OlaHsd
Is Recombinase	false	Is Wild Type	false

molecularNote

The single coding exon was deleted via Cre-mediated recombination of flanking loxP sites. RNA in situ hybridization confirmed the absence of transcript expression in E12.5 homozygous mutant embryos.

mutations:
Intragenic deletion

cellLines:
Not Specified

synonyms:
Ccdc8<->,
Ccdc8<KO>,
Ccdc8<KO>,
Ccdc8<->

earliestPublication:
Wang P, et al. (2019) Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. J Clin Invest 129(10):4393-4407

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

4 Publication categories

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