| Primary Identifier | MGI:6763025 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Ace2 |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | CRISPR/cas9 endonuclease-mediated genome editing is used to insert an amino acid substitution at position 82 altering serine to methionine (S82M - AGT to ATG) . The mutation is designed to partially humanize the mouse Ace2 coding sequence in a region important for binding to the SARS-CoV-2 spike protein. |
