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Allele : Kdm2b<em1Zhanz> lysine (K)-specific demethylase 2B; endonuclease-mediated mutation 1, Zhenzhen Zhan

Primary Identifier	MGI:6883557	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout	Gene	Kdm2b
Strain of Origin	Not Specified	Is Recombinase	false
Is Wild Type	false

molecularNote

Using the CRISPR-Cas9 system, seventeen bases of the Jmjc domain responsible for its demethylase activity were deleted from the Kdm2b gene resulting in a frameshift mutation.

mutations:
Intragenic deletion

synonyms:
Kdm2b<->,
Kdm2b<->

earliestPublication:
Zhou Q, et al. (2020) KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling. Cell Mol Immunol 17(8):834-842

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

2 Publication categories

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