| Primary Identifier | MGI:7414359 | Allele Type | Targeted |
| Attribute String | Conditional ready, Hypomorph | Gene | Wapl |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The targeting vector is designed to insert a loxP site upstream of the endogenous promoter (- 517 bp relative to major transcriptional start site), and a loxP site downstream of exon 2 (+3641 relative to the major transcriptional start site). An FRT-flanked neomycin cassette is also part of the construct. Flp-mediated recombination removed the neo cassette. This allele is a hypomorph, although RNA levels are not altered, WAPL protein levels are reduced by 2 fold. |
