| Primary Identifier | MGI:7278818 | Allele Type | Endonuclease-mediated |
| Attribute String | Humanized sequence | Gene | Ifih1 |
| Strain of Origin | C57BL/6N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Using crRNA and tracrRNA (targeting GTCATTAGTAAATTTCGCAC) and an ssODN template (TTCTTCTCCTAATTAGAAGATCTGAATGTGTTTAGCATCACAAAATTTAATTTATTAAAAATGTTTCCACAGACTGAACAAAAAGAAGTCATTAGTAAATTTCACACTGGCGAAATAAATCTGCTTATCGCTACGACGGTGGCAGAGGAAGGCCTGGATATCAAAGAGTGCAATATTGTTATTCGTTATGGCCTTGTC) with CRISPR/Cas9 technology, arginine codon 779 (CGC) was changed to histidine (CAC) (c.2336G>A, p.R779H). This mutation mimics one found in Aicardi-Goutieres Syndrome (AGS) patients. |
