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Allele : Nars1<em2Rwb> asparaginyl-tRNA synthetase 1; endonuclease-mediated mutation 2, Robert W Burgess

Primary Identifier  MGI:7310307 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Nars1
Inheritance Mode  Recessive Strain of Origin  C57BL/6J
Is Recombinase  false Is Wild Type  false
molecularNote  The CRISPR/cas9-induced Ser472Phe point substitution in exon 13 that was also created in the em1Rwb allele is preceded by an 8 base pair deletion that causes a frame shift and premature truncation. qRT-PCR of heterozygotes shows an approximate 50% loss of transcript relative to wild-type.
  • mutations:
  • Intragenic deletion
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

3 Publication categories