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Allele : Mir592<em1Jzhan> microRNA 592; endonuclease-mediated mutation 1, Jing Zhang

Primary Identifier	MGI:7310355	Allele Type	Endonuclease-mediated
Attribute String	Null/knockout	Gene	Mir592
Strain of Origin	Not Specified	Is Recombinase	false
Is Wild Type	false

molecularNote

CRISPR/Cas9 technology generated a 157 bp deletion in the untranslated exon region of Grm8. Mir592 is in this untranslated exon region and RT-PCR confirmed knock-out of Mir592. Isoform-sequencing indicates that Grm8 is not affected by knocking out Mir592.

mutations:
Intragenic deletion

synonyms:
miR-592<->,
miR-592<->

earliestPublication:
Fu Y, et al. (2022) Loss of neurodevelopmental-associated miR-592 impairs neurogenesis and causes social interaction deficits. Cell Death Dis 13(4):292

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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