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Allele : Hdc<em1Huhu> histidine decarboxylase; endonuclease-mediated mutation 1, Hua Huang

Primary Identifier	MGI:7330187	Allele Type	Endonuclease-mediated
Gene	Hdc	Strain of Origin	BALB/c
Is Recombinase	false	Is Wild Type	false

molecularNote

CRISPR/cas9 genome editing is used to delete sequences incorporating the noncoding GC box sequence (GGGCGG). The GC box sequences possess enhancer activity. mRNA expression is reduced in mast cells, basophils, brain cells, and stomach cells.

mutations:
Intragenic deletion

synonyms:
Hdc<em1Huhua>,
Hdc<GC>,
Hdc<GC>,
Hdc<em1Huhua>

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

3 Publication categories

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