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Allele : Trim28<tm1.1Ics> tripartite motif-containing 28; targeted mutation 1.1, Mouse Clinical Institute
Primary Identifier  MGI:7471137 Allele Type  Targeted
Attribute String  Not Specified Gene  Trim28
Transmission  Germline Strain of Origin  C57BL/6NCrl
Is Recombinase  false Is Wild Type  false
molecularNote  Cysteine codon 651 (TGC) in exon 13 was changed to phenylalanine (TTT) (p.C651F) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 3. The neo cassette was removed through subsequent Cre-mediated recombination. The mutation is located in the PHD domain of the encoded peptide and abrogates its SUMO-E3-ligase activity.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Trim28<C651F>,
  • Trim28<PHD>,
  • Trim28<PHD>,
  • Trim28<C651F>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories





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