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Allele : Puf60<tm1.1Kmtsu> poly-U binding splicing factor 60; targeted mutation 1.1, Kazuyuki Matsushita

Primary Identifier	MGI:7487995	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Puf60
Transmission	Germline	Strain of Origin	(C57BL/6NCrlj x CBA/JNCrlj)F1
Is Recombinase	false	Is Wild Type	false

molecularNote

The targeting construct inserted a loxP upstream of exon 3 and a neomycin resistance cassette with a 3' loxP downstream of exon 4. Cre-mediated recombination removed exons 3 and 4 along with the selection cassette.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

earliestPublication:
Matsushita K, et al. (2015) Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1. Oncotarget 6(7):5102-17

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

4 Publication categories

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