| Help | About | Contact Us

Allele : Dis3l2<em1Dean> DIS3 like 3'-5' exoribonuclease 2; endonuclease-mediated mutation 1, Jurien Dean

Primary Identifier	MGI:7495776	Allele Type	Endonuclease-mediated
Attribute String	Conditional ready	Gene	Dis3l2
Strain of Origin	(C57BL/6 x DBA/2)F1	Is Recombinase	false
Is Wild Type	false

molecularNote

CRISPR/Cas9 genome editing technology was used to insert loxP sites flanking exon 2. qPCR confirmed the depletion of Dis3l2 transcripts in growing and fully grown germinal vesicle (GV) oocytes.

mutations:
Insertion

synonyms:
Dis3l2 floxed,
Dis3l2 floxed

earliestPublication:
Wu D, et al. (2023) DIS3L2 ribonuclease degrades terminal-uridylated RNA to ensure oocyte maturation and female fertility. Nucleic Acids Res 51(7):3078-3093

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/report.do?id=76829416

MouseMine