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Allele : Ripk1<em2Dov> receptor (TNFRSF)-interacting serine-threonine kinase 1; endonuclease-mediated mutation 2, Domagoj Vucic

Primary Identifier  MGI:7547313 Allele Type  Endonuclease-mediated
Gene  Ripk1 Is Recombinase  false
Is Wild Type  false
molecularNote  Lysine codon 376 (AAG) in exon 9 was changed to arginine (CGA) (p.K376R) using an sgRNA (targeting CGAGAATGATCGCAGTGTGC) and an ssODN template using CRISPR/Cas9 technology. The mutation affects ubiquination at the residue in the encoded peptide.
  • mutations:
  • Nucleotide substitutions
  • synonyms:
  • Ripk1<K376R>,
  • Ripk1<K376R>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

2 Publication categories